Zebrafish Embryo as an Emerging Model Organism in Neurodevelopmental Toxicity Research

Zebrafish is a model organism that has become increasingly popular in recent years due to some of the advantages it when compared traditional organisms. Its genetic similarity with humans contributed significantly elucidation molecular mechanisms underlying diseases. Moreover, external fertilization and rapid embryonic development zebrafish embryos have made attractive many research areas. The genome are found be highly conserved having 76-82 % disease genes also present zebrafish. been used different studies several concepts neurogenesis. Unlike mammals, embryo makes accessible for experimental manipulation central nervous system research. It was observed neurotoxic agents induced similar responses other vertebral models embryos, whose brain blood-brain barrier were those vertebrates. This review provides brief information about availability neurodevelopmental toxicity while giving on embryogenesis neurogenesis Evaluation neurotoxicity specific effects various neurotoxins motor dopaminergic neurons, neuronal proliferation, mobility, neurodevelopment explained.